Product Name :
2′-Deoxyinosine (CAS 890-38-0)
Synonym :
9-(2-Deoxy-β-D-ribofuranosyl)hypoxanthine
Application :
2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond
CAS:
890-38-0
Purity:
≥98%
Molecular Weight:
252.23
Formula :
C10H12N4O4
Physical state:
Solid
solubility :
Soluble in water, and 1 M NH4OH (50 mg/ml).
Shipping Condition :
Store at -20° C
Melting point:
250° C
SMILES:
C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2NC=NC3=O)CO)O
References:
:Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2′-deoxyinosine: a new chemoenzymatic synthesis of the antiviral drug 2′,3′-dideoxyinosine.Bicyclo[2.2.1]Hept-5-en-2-one Price | Ciuffreda, P., et al.BuyAzido-C6-OH 1999. Bioorg Med Chem Lett. 9: 1577-82. PMID: 10386939Thermal stability of triple helical DNAs containing 2′-deoxyinosine and 2′-deoxyxanthosine. | Ueno, Y., et al. 2004. Bioorg Med Chem. 12: 6581-6. PMID: 15556774Development of stealth liposome formulation of 2′-deoxyinosine as 5-fluorouracil modulator: in vitro and in vivo study. | Fanciullino, R., et al. 2005. Pharm Res. 22: 2051-7. PMID: 16222443Quantitative gas chromatography mass spectrometric analysis of 2′-deoxyinosine in tissue DNA. | Lim, KS., et al. 2006. Nat Protoc. 1: 1995-2002. PMID: 17487188Miscoding properties of 2′-deoxyinosine, a nitric oxide-derived DNA Adduct, during translesion synthesis catalyzed by human DNA polymerases. | Yasui, M., et al. 2008. J Mol Biol. 377: 1015-23. PMID: 18304575Hybridization-sensitive fluorescent DNA probe with self-avoidance ability. | Ikeda, S., et al. 2010. Org Biomol Chem. 8: 546-51. PMID: 20090970Electrochemical genotyping and detection of single-nucleotide polymorphisms based on junction-probe containing 2′-deoxyinosine. | Zhang, J., et al. 2010. Chem Commun (Camb). 46: 6986-8. PMID: 20730202Nucleoterpenes of thymidine and 2′-deoxyinosine: synthons for a biomimetic lipophilization of oligonucleotides. | Köstler, K., et al. 2013. Chem Biodivers. 10: 39-61. PMID: 23341207Chemical Constituents of Cordyceps cicadae.PMID:33725178 | Chu, ZB., et al. 2015. Nat Prod Commun. 10: 2145-6. PMID: 26882686Bioactivity of 2′-deoxyinosine-incorporated aptamer AS1411. | Fan, X., et al. 2016. Sci Rep. 6: 25799. PMID: 27194215The Bioactivity of D-/L-Isonucleoside- and 2′-Deoxyinosine-Incorporated Aptamer AS1411s Including DNA Replication/MicroRNA Expression. | Fan, X., et al. 2017. Mol Ther Nucleic Acids. 9: 218-229. PMID: 29246300Enhancement of exon skipping activity by reduction in the secondary structure content of LNA-based splice-switching oligonucleotides. | Shimo, T., et al. 2019. Chem Commun (Camb). 55: 6850-6853. PMID: 31123731Therapeutic Perspectives of Adenosine Deaminase Inhibition in Cardiovascular Diseases. | Kutryb-Zajac, B., et al. 2020. Molecules. 25: PMID: 33053898