Product Name :
21(R)-Hydroxy Montelukast (CAS 184763-26-6)
Synonym :
[R-[R*,R*-(E)]]-1-[[[1-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxy-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropaneacetic Acid
Application :
21(R)-Hydroxy Montelukast is a benzylic hydroxylated metabolite of Montelukast
CAS:
184763-26-6
Purity:
Molecular Weight:
602.18
Formula :
C35H36ClNO4S
Physical state:
Solid
solubility :
Shipping Condition :
Store at -20° C
Melting point:
76-81° C
SMILES:
CC(C)(C1=CC=CC=C1[C@@H](C[C@H](C2=CC=CC(=C2)/C=C/C3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)O)O)O
References:
:Montelukast dose selection in 6- to 14-year-olds: comparison of single-dose pharmacokinetics in children and adults. | Knorr, B., et al. 1999. J Clin Pharmacol. 39: 786-93. PMID: 10434229In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases.Buy2-Fluoroacrylic acid | Cardoso, Jde O.212127-83-8 Chemscene , et al.PMID:33467950 2015. Drug Metab Dispos. 43: 1905-16. PMID: 26374173Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile. | Balani, SK., et al. 1997. Drug Metab Dispos. 25: 1282-7. PMID: 9351905